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WFH 2012 World Congress

 

8-12 July, 2012 Paris, FRANCE
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Discussion forum - WFH 2012 World Congress
    Topic - Inhibitors Pathogenesis, Prevention and Treatment

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Poster: 122
Visits: 553
Title: IgG4 subclass of anti-FVIII antibodies is correlated to high-titer inhibitor,whereas IgG1 subclass is related to low-titer inhibitor in hemophilia Apatients.
Authors: Margareth Ozelo , Silmara Aparecida de Lima Montalvao, Thais Trento, Marcelo Veiga, Maria Cristina Montenegro, Anelisa Streva, Erich Vinicius De Paula, Marina Pereira Colella
Centre: UNICAMP

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IGG4 SUBCLASS OF ANTI-FVIII ANTIBODIES IS CORRELATED TO HIGH-TITER INHIBITOR,WHEREAS IGG1 SUBCLASS IS RELATED TO LOW-TITER INHIBITOR IN HEMOPHILIA APATIENTS.

Margareth Ozelo
Thread initiator
Subspeciality
Reg: 6/25/2012 5:38:00 PM
Comment# 1
The characterization of immunoglobulin (Ig) subclass has been showed an important role to identify the reactivity of factor (F) VIII concentrate used in the treatment of patients with hemophilia A (HA). Recent studies showed a strong correlation between high levels of anti-FVIII antibodies of subclass IgG4 with high-titre inhibitor and immune tolerance induction (ITI) failure. The objective of this study was to evaluate the characteristics of anti-FVIII IgG subclasses in HA patients with inhibitor

Comment added on 6/25/2012 5:38:00 PM 
     
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Most viewed poster for this congress
Poster: 243
Visits: 2712
Title: Use of the Exergaming (Nintendo Wii) in the Rehabilitation of Patients withHemophilia.
Authors: JANAINA BOSSO JOSÉ DA SILVA , Rafael Fagnani, Egritti de Oliveira Zacarias da Silva,Marcia Aparecida Picoloto Matta, Margareth Castro Ozelo
Centre: UNICAMP

Poster most viewed in this topic
Poster: 133
Visits: 881
Title: A Canadian survey on the incidence and risk factors for inhibitor development insevere hemophilia A PUPs: 2005-2010.
Authors: Georges-Etienne Rivard , M. Carcao, C. Infante-Rivard, A.M. StainE. Paradis, J. Teitel
Centre: CHU Sainte-Justine, Montréal, QC, Canada


 
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